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People with mutations in the enzymes that form glutathione are more susceptible to oxidative stress

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[DOI] [PMC free article] [PubMed] [Google Scholar] 43.Zhang J., Ye Z.W., Singh S., Townsend D.M., Tew K.D

Figure 3 BDG Induces Glutathione Synthesis and Metabolism in Human Monocytes Given that glutathione metabolism was enriched in the gene ontology of upregulated genes and that glutathione synthesis/metabolism are regulated by NRF2, a TF whose gene expression is increased after BDG exposure and motif is enriched in all the ATAC-seq groups, we sought to investigate the effect of BDG on this pathway in human monocytes ( Figure 4A )